Gift Motupa scored four goals for Bidvest Wits, while Nigerian sides Enyimba and Enugu Rangers made contrasting progress in CAF Confederation Cup play-offs.
Motupa netted the first four goals as Wits crushed UD Songo of Mozambique 6-0 in Johannesburg after taking a 2-1 lead into the second leg.
It was the first time in seven attempts that Wits have qualified for the mini-league phase of a competition.
Enyimba had a comfortable passage and Enugu a nervous one as both continued campaigns to become the first Nigerian winners of the Confederation Cup.
Having built a 2-0 advantage at home to second division side TS Galaxy, Enyimba doubled their aggregate advantage through goals from Daniel Darkwah and Martins Usule.
Galaxy finished 2-1 second leg losers in Nelspruit when Terrence Mashego grabbed a consolation goal one minute from time.