Jose Mourinho returns to the Old Trafford dugout almost a year after his last appearance, for a 4-1 win over Fulham on 8 December 2018 that proved to be his last victory as Manchester United manager.
The away side won both Premier League meetings last season.
Tottenham have lost 34 Premier League games against Manchester United, more than they have against any other side.
Prior to winning 3-0 last season, Spurs had lost four consecutive league matches at Old Trafford without scoring.
United are aiming to win consecutive Premier League matches against Spurs for the first time since 2015.
Manchester United's current three-match unbeaten league run is their longest of the season (W1, D2).
United have gone eight home matches without defeat in all competitions (W4, D4).
However, this is still their worst start to a league season since 1988-89. They have picked up just 18 points from their opening 14 matches.
They have only kept two clean sheets in their last 25 top-flight games.
United have missed four of their six penalties in the league this season. The Premier League record for most missed penalties in a single campaign is five by Tottenham (1994-95) and Liverpool (2011-12).
Jesse Lingard was directly involved in six goals in seven league matches in December 2018. He has neither scored nor provided an assist in any of his subsequent 22 league appearances.
Jose Mourinho could become the first Spurs manager to win his opening three top-flight games in charge of the club.
Nonetheless, Tottenham have won just one of their seven away matches in this season's Premier League (D3, L3).
They could concede a goal in 10 consecutive league matches for the first time since a run of 17 games from August to December 2010.
Spurs are also on a club record streak of 14 consecutive Premier League away matches without a clean sheet. It's their worst such run since 1979.
Dele Alli has been directly involved in three goals in his last two Premier League games, as many as he had in his final 12 appearances under Mauricio Pochettino.
Harry Kane has scored only two goals in 10 Premier League appearances against Manchester United, averaging a goal every 412 minutes - the worst minutes-per-goal ratio of the 28 teams he has scored against in the top flight.
Premier League Results: (03 December)
Crystal Palace 1 Bournemouth 0.
Burnley 1 Manchester City 4.
Premier League Fixtures:(04 December).
Chelsea vs. Aston Villa @ 19:30.
Leicester vs. Watford @ 19:30.
Manchester United vs. Tottenham @ 19:30.
Southampton vs. Norwich City @ 19:30.
Wolves vs. West Ham @ 19:30.
Liverpool vs. Everton @ 20:15.
Premier League Fixtures: (05 December).
Sheffield United vs. Newcastle @ 19:30.
Arsenal vs. Brighton @ 20:15.