Cape Town City who won the trophy last season after beating SuperSport United in the final on penalties, will play Polokwane City at Newlands Stadium at 15:00.
The PSL has confirmed all quarter-final fixtures that will be played on Saturday and Sunday.
Tickets will be selling at R40 for adults and R15 for children under the age of 12.
Saturday, August 17
Cape Town City v Polokwane City, Newlands Stadium - 15:00
Orlando Pirates v Highlands Park, Orlando Stadium - 18:00
Mamelodi Sundowns v Bloemfontein Celtic,Lucas Moripe Stadium - 20:15
Sunday, August 18
Bidvest Wits v SuperSport United,Bidvest Stadium - 15:00