Mosimane has been at the helm of Sundowns for seven years where he had an overhaul of trophies including the CAF Champions League and the Super Cup.
"It is with a sense of pain and sadness that I announce my departure from Mamelodi Sundowns Football Club. Ihave accepted an offer to join an international team," said Mosimane in a statement. "Mamelodi Sundowns has been my family for almost eight years. The President Dr Patrice Motsepe has been like a father to me. He has been a mentor, a friend, a supporter and a confidante. I could never quit him or Mamelodi Sundowns.
"I am only going away to carry the spirit of the Yellow Nation with me. After winning five league titles with Mamelodi Sundowns – the 10th for the club – how can a man ever find it easy to say goodbye to his home? How can I say goodbye to the family, the board, the supporters and the fans?
"From the deepest of my heart, I am so grateful that the President has blessed my move. I did not expect lessfrom a man who has been so good and generous to me. He is the kind of leader any family, company, team and indeed any country needs. I have been privileged to drink from his well of wisdom.
"My success is his success. Without him, I would not have achieved half of what I have. I leave this family knowingthat our bond is unbreakable and hoping that with the passage of time, our paths would come together again," he said.
The highly successful coach seem to have left the door open for a possible return to the in future. "This is not a divorce. We shall remain bonded forever I am taking up this new challenge that will push me out of my comfort zone. I know Mamelodi Sundowns will use this as a fresh and new perspective," he said.
"While I had four years remaining in my contract, this offer is a huge opportunity for me that would not havecome had I not had the privilege to be part of the team that led Mamelodi Sundowns in winning the CAF Champions League and reaching the Club World Cup finals," said Mosimane.
Club boss Dr Patrice Motsepe said in a statement that he approved and supported Mosimane‘s departure Sundowns for a top Egyptian club.
“Pitso Mosimane and his agent Moira Tlhagale, who is also his wife, came to brief me on the discussions between Pitso Mosimane and a top Egyptian club. Sundowns has been aware of the ongoing discussions between Pitso Mosimaneand the Egyptian club and with other North African clubs," said Motsepe.
"I have on several occasions over the past few years expressed my support for Pitso Mosimane leaving Sundowns to coach in North Africa or Europe or Bafana Bafana. Football players and coaches have at times an uncertain and inconsistent future and must pursue new opportunities where they may grow and receive greaterremuneration.
The club said they would make announcements in due course concerning the new head coach and other changes that they will be introducing.