Gareth Bale is set to miss "a few weeks" with a calf strain, says Tottenham boss Jose Mourinho.
Bale has made 11 appearances, scoring three goals, since returning to Spurs on loan from Real Madrid in September.
"I wouldn't say it's serious," added Mourinho, whose side play Fulham in the Premier League on Wednesday before taking on Leeds on Saturday, 2 January.
Spurs then face Brentford in the semi-finals of the Carabao Cup on 5 January, and travel to Marine in the third round of the FA Cup on 10 January.
Meanwhile the latest round of Premier League coronavirus testing found 18 people had the virus - the highest figure recorded in the league's testing programme.
The 18 positives come from 1,479 tests on players and staff between 21 and 27 December, a rate of 1.22%.
The round that produced 16 positives was from 1,207 tests at 1.33%.
The previous round of Premier League testing, from 14-20 Dec, returned seven positives. The league began testing on 31 August.