Aston Villa's Premier League game at home to Everton on Sunday has been postponed because of the ongoing Covid-19 issues at the club.
A Premier League statement said that a "significant number" of Villa players and staff remained in isolation.
It went on: "As a result, the Premier League board has agreed to Aston Villa's request to postpone their match on Sunday."
Villa, who already have three games in hand on some clubs in the league, are due to play Manchester City on Wednesday.
That game was originally scheduled to take place on the opening weekend of the season but was postponed because of City's progress in last season's Champions League.
One of the matches they have in hand - the game at home to Newcastle, which was postponed from 4 December after the Magpies' own coronavirus outbreak - has been rescheduled for Saturday, 23 January.
Villa's Covid-19 outbreak meant that no first-team players were available for the FA Cup third-round tie against Liverpool last Friday.
Meanwhile the Premier League is to meet club managers and captains to discuss adherence to the new Covid-19 protocols that were released earlier this week.
It has been stressed that protocols, including avoiding "unnecessary contact", need to be enforced.
There were goal celebrations involving Sheffield United, Manchester United, Manchester City and Fulham this week.