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Scotland claimed a first win at Twickenham since 1983 as returning fly-half Finn Russell orchestrated a shock 11-6 Six Nations victory over England.
Capitalising on the hosts' ill discipline, Russell gave Scotland a three-point lead before helping to set up Duhan van der Merwe's try.
Defending champions England clawed back six points and Russell's charge was briefly halted by a yellow card.
But a resilient Scotland were undeterred and added another penalty.
England had been favourites to win the tournament but, with France having opened their Six Nations with a 50-10 defeat of Italy, their chances suddenly seem much slimmer.
Scotland, on the other hand, look likely to improve on last year's fourth-place finish with Wales their opponents at Murrayfield next weekend.
That is one of three home games for the Scots in the 2021 Six Nations, with round three's trip to Paris now looking decisive for their title hopes.
There was no shortage of history surrounding the Calcutta Cup match. It marked the 150th anniversary of the first time England and Scotland played each other and the fact Scotland were without a win at Twickenham in 38 years was a key talking point in the build-up.
All the players had been confined to coronavirus bubbles in the week before the tournament, with England only allowed to socialise outside or otherwise stay alone in their rooms.
Some had said that at an empty Twickenham and with several England leaders missing, this was Scotland's best chance of a win since 1983.