Swallows FC will test their unbeaten run this season against in-form AmaZulu, who have shown attacking verve under new coach Benni McCarthy.
The Birds are unbeaten in 15 games this campaign and lost just one of their last 32, but there have been signs of late that they are creaking.
Three successive draws in the league were followed by a slender 1-0 win over second-tier Cape United in the Nedbank Cup, and you get the feeling that if AmaZulu take the game to them, The Birds could buckle.
Usuthu have lost just one of their nine games under McCarthy and showed great fighting spirit to get a penalty shoot-out win over Lamontville Golden Arrows in the Nedbank Cup – the kind of battling performance that McCarthy demands of his teams.
They have drawn four of their last five games on the road 1-1, to go with a 2-0 success at Baroka FC, and McCarthy has certainly made them a hard team to beat.
But Swallows have taken 14 points from 18 at home this campaign and conceded only three goals in that time. They know how to grind out results.
The last time these sides met they were both in the GladAfrica Championship in the 2015-16 season, with Usuthu claiming a 2-1 away win.
Meanwhile SuperSport United and Cape Town City will both be looking to bounce back to winning ways in the 2020-21 DStv Premiership season when they meet at Lucas Moripe Stadium on Saturday.
SuperSport’s last home match in the Premiership saw them held 1-1 by Swallows FC in late January, with the Tshwane side conceding a late equaliser after claiming an early lead through Lucky Mohomi’s deflected strike.
Matsatsantsa have claimed 16 points from eight home matches this season and have yet to taste defeat as hosts in the current campaign. Mohomi was also on the scoresheet away to Bloemfontein Celtic earlier this week in a 2-1 defeat.
Elsewhere Mamelodi Sundowns and Al-Hilal Omdurman will meet in a Group B 2020-21 Caf Champions League opener at Loftus Versfeld Stadium on Saturday evening.
Both teams are yet to lose a league game this season heading into this weekend's round of continental fixtures. Sundowns sit top of the DStv Premiership standings having yet to taste defeat at the halfway mark of the current campaign. Al-Hilal are unbeaten in eight Sundani Premier League matches and currently occupy second spot.
Sundowns booked their place in the group stages with a 5-1 aggregate win over Botswana's Jwaneng Galaxy. The South African champions will be aiming to conquer Africa for a second time following their success in 2016 under Pitso Mosimane, who won the tournament with Al Ahly last season.
While Al-Hilal booked their spot in the group stages of this season's competition with aggregate wins over Ugandan club Vipers and Ghanian outfit Asante Kotoko in the preliminary and first round respectively.The Blue Wave, who lost in the final of Africa's premier cup competition in both 1987 and 1992, beat Sundowns 4-3 on aggregate enroute to qualifying for the 2008 Caf Champions League group stages at the expense of the Tshwane giants.
The two matches account for the only previous meeting between the two clubs.TP Mazembe (Democratic Republic of Congo) and CR Belouizdad (Algeria) complete Group B.