Mamelodi Sundowns will be fighting to reclaim the top spot while Orlando Pirates continue with their chase of a Caf Champions League berth when the heavyweights clash in a Premier Soccer League showdown at Orlando Stadium this afternoon.
Kick-off is at 3pm CAT (SA, GMT+2).
Sundowns have gone three league matches without a win and saw their lead at the top of the log cut to one point when they were held 0-0 at home by Golden Arrows on 28 April.
The Brazilians have claimed 25 points from 11 away matches this season, with their last result on the road a 0-0 draw at AmaZulu in April.
"I think if I was at Pirates I'd say to myself that it would be nothing but a disaster not to consider ourselves to be in the title race. Mathematically it's still very possible that they can still win the title," said Sundowns co-coach Rulani Mokwena.
"I would think the standard that they've set... the work that they've done, the recruitment that they've made and the investment that has gone into the club this season should suggest that they should be winning more games and they should be putting more pressure [on their title rivals].
"History dictates that we've been chasing in the past. I can assure you that the pressure of chasing is far worse than the pressure of being on top. I'd always like to be No 1 because at this moment in time we have our own destiny within our control."
Pirates played to their ninth draw of the season when they were held 1-1 at Soweto rivals Swallows FC on 24 April, with Tshegofatso Mabasa netting their equaliser.