The N3 south has been temporarily closed between Pietermaritzburg and Durban in KwaZulu-Natal (KZN) following a deadly accident on Wednesday morning.
Two people have been killed and 12 others injured in another major crash on the N3 highway near Pietermaritzburg.
This after a container fell off a truck and onto a minibus taxi.
The highway is closed for the second day in a row.
"It is believed that a container fell off a truck and landed on top of a fully-loaded minibus which was traveling in the same direction," said KZN EMS spokesperson, Robert McKenzie.
"Two people have sustained injuries in this incident and paramedics have treated 12 patients at the scene."
McKenzie adds local authorities are on the scene.
This is the second fatal incident on the N3 in some 24 hours after a crash left a 30-year-old man dead near Van Reenen's Pass on Tuesday morning.