The US Treasury has imposed sanctions against the Gupta family and an associate over alleged corruption in South Africa.
The sanctions were targeted at brothers Atul, Ajay and Rajesh Gupta, and businessman Salim Essa.
They are accused of using their friendship with former president Jacob Zuma,to profit financially and influence ministerial appointments.
The accused have denied any wrongdoing.
"The Gupta family leveraged its political connections to engage in widespread corruption and bribery, capture government contracts, and misappropriate state assets," said Sigal Mandelker, the Treasury Under Secretary for Terrorism and Financial Intelligence.
The Treasury said the sanctions would target the Guptas "pay-to-play political patronage" in South Africa, but did not elaborate on the details.
"We will continue to exclude from the US financial system those who profit from corruption," the Treasury added.
In a statement, South Africa's Department of Justice said the sanctions will ensure the accused "are prohibited from conducting any business in the USA or with any American company worldwide".
The Guptas have since fled South Africa, and are said to be living in Dubai.